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A common DIO2 haplotype composed of the minor C-allele of SNP rs225014 and the common C-allele of SNP rs12885300 was significantly associated with advanced hip OA, as indicated by a higher odds ratio 101,102,103

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Acknowledgements This work was partially supported by the Finish Line grant of Markey Cancer Center to H.S.Y as well as the Biostatistics and Bioinformatics, Biospecimen Procurement and Translational Pathology, and Flow Cytometry and Immune Monitoring Shared Resource facilities of the University of Kentucky Markey Cancer Center (P30CA177558)